2025 NFL Week 2 odds, betting: Full list of Week 2 spreads

The 2025-26 NFL regular season has begun and Week 1 was quite the start for under bettors, with Week 1 games going 12-3 to the under before Monday Night Football between the Minnesota Vikings and Chicago Bears.

It’s never too early to look ahead to next week, though, and sportsbooks have already posted lines for every matchup.

Here are the odds for every Week 2 game at BetMGM:

Thursday, Sept. 11

Washington Commanders at Green Bay Packers (-3.5, 48.5)

1 p.m. ET games

Buffalo Bills (-7.5, 45.5) at New York Jets

New England Patriots at Miami Dolphins (-1.5, 44.5)

Jacksonville Jaguars at Cincinnati Bengals (-3.5, 50.5)

Cleveland Browns at Baltimore Ravens (-12.5, 45.5)

New York Giants at Dallas Cowboys (-4.5, 44.5)

Los Angeles Rams (-5.5, 42.5) at Tennessee Titans

Chicago Bears at Detroit Lions (-4.5, 47.5)

Seattle Seahawks at Pittsburgh Steelers (-3, 40.5)

San Francisco 49ers (-6.5, 43.5) at New Orleans Saints

4 p.m. ET games

Carolina Panthers at Arizona Cardinals (-7, 45.5)

Denver Broncos (-2.5, 43.5) at Indianapolis Colts

Philadelphia Eagles (-1, 45.5) at Kansas City Chiefs

Sunday Night Football

Atlanta Falcons at Minnesota Vikings (-4.5, 45.5)

Monday, Sept. 15

Tampa Bay Buccaneers at Houston Texans (-1.5, 44.5)

Los Angeles Chargers (-3.5, 45.5) at Las Vegas Raiders

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